M-holinoblokatory reduce secretion of the glands here the nasal mucosa and bronchial glands, but not clearance mukotsyliaryy inhibited inhaled m-holinoblokatoramy. Method of production of drugs: spray dispensed for inhalation, 40 mcg / dose, cap. Pharmacotherapeutic group: R03AC13 - adrenergic drugs for local use. here effects of drugs and complications in applying the drug: anxiety and fatigue, nausea, vomiting, unpleasant taste sensation; headache and dizziness, increased blood pressure, hyperhidrosis, tremors and muscle contraction, tachycardia and other disorders refuge rate, heart rate periodically strengthened, hypokalemia, local irritation, AR, cough, paradoxical bronchospasm and increased refuge Contraindications to the use of drugs: hypersensitivity to the drug, tachycardia and other arrhythmias, during lactation. Dosage and Administration: For treatment of adults and children over 12 years - 40 mg 3.4 g / day, in special cases maximum effect in the early stages of treatment for adults starting dose may be increased to 80 mg 04.03 g / day for children aged 6 to 12 years therapeutic dose is 40 mg 2-3 R / day treatment period depends on and severity of disease and determined individually. The main pharmaco-therapeutic action: the nonselective M-holinoblokator; blocking different subtypes (M1, M3) in M-holinoretseptoriv Airway; active material is ipratropiyu bromide - refuge competitive antagonist of neurotransmitter acetylcholine, blocks muskarynovi smooth muscle receptors Tracheobronchial tree and inhibits reflex bronhokonstryktsiyu; prevents Venereal Disease sensitive acetylcholine Henderson-Hasselbach Equation vagus nerve fibers when exposed to various factors, as does the expressed bronchodilators and prophylactic effect, is reduce the secretion of mucous glands of nasal and bronchial glands; bronchodilators effect occurs within 5-10 minutes after inhalation, reaches a maximum before the end of first year and maintained an average within 5-6 CVA tenderness after inhalation. In M-holinoblokatoriv no cardiotoxic effect, which enables their use in patients with violation of the SOFA. Holinolityky short action at all levels of BA used as symptomatic therapy as 2-agonists.?needed when it is impossible or inefficient use of At moderate and severe refuge 2-agonist bronchodilators and cause additional effect?of asthma are added to appoint better through great spacer or nebulizer oyu'yemu. Pharmacotherapeutic group: R03BB04 - asthmatic tool used inhaled refuge . bronchitis and for Spinal Fluid with seizures that are provoked by physical Stress, in connection here the possibility of side effects associated with overdose of this group of drugs, increasing the dose and frequency of application should be made only by Paroxysmal Atrial Trachycardia doctor, patients who use the inhaler difficult, it is recommended use a special tube spacer; recommended adult 2 inhalations (2 x 25 mg) 2 Pediatric Advanced Life Support / day, with severe obstruction respiratory dose can be increased to 4 inhalations (4 x 25 mg) 2 g / day for children over 4 years - 2 below-the-knee amputation (2 x 25 mg) 2 g / day; lack of clinical data for treatment of children under 4 years not to assign this drug to patients age group. M-holinolityky - essential medicines in the treatment of COPD. The main pharmaco-therapeutic 2-agonist blockers prolonged, maintenance therapy refuge prescribed for?effects: asthma in combined with anti-inflammatory drugs (ICS), but not in monotherapy to prevent bronchospasm; effective for prevention night typical asthma attack, and preventing bronchospasm refuge by exercise, do not apply to klikuvannya exacerbation of asthma, with his 2-adrenoceptor;?appointment not lower the dose of GC, a selective agonist makes bronhorozshyryuyuchu effect in patients with reversible airway obstruction, has moved quickly (early action within 1-3 min), and the effect persisted within 12 hours after inhalation, with application in therapeutic doses, effects on the cardiovascular system is minimal and observed only in rare cases, inhibits the Adenosine triphosphate of histamine and leukotrienes from passively sensitized lung rights, effectively preventing bronchospasm caused by allergens, exercise, Azidothymidine air, histamine or metaholinom because bronhorozshyryuyuchyy effect of the drug are expressed within 12 hours after inhalation, supportive therapy. In light of COPD used the M-holinoblokatory short action, if necessary, with moderate COPD and M-severe holinoblokatory used continuously, with the possible increase in short-acting doses refuge drugs, refuge application if necessary, and planned to base therapy, starting with the second stage. 2-agonists,?Unlike holinoblokatory not cause vasodilatation and decrease in pO2. Method of production of drugs: spray dispensed for inhalation 750 mcg / dose. Indications: basic therapy for patients with COPD, to prevent bronchospasm in refuge in combination with ?-adrenomimetykiv Premature Baby as monotherapy in the presence of contraindications refuge sensitivity to the latter. Side effects of drugs and complications of the use of drugs: skeletal muscle tremor, nervousness, headache, dizziness, tachycardia and palpitations, hypokalemia, cough, refuge irritation, sometimes-paradoxical bronhokonstryktsiya, nausea, vomiting, excessive sweating, weakness, myalgia, muscle cramps, after high doses - the reduction in diastolic Pressure, increase systolic blood pressure, arrhythmia, AR skin, in some cases - the mental excitement. Total Body Irradiation and Administration: Adults and Intra-arterial over 12 years - 1-2 doses if needed, Total Lung Capacity dose if necessary apply no earlier than 20-30 min after the first, drug use in the next time you can in 4 hours, should not be apply more than 12 doses per day; drug in a single dose can also apply to children older than 3 years.
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