Indications for use drugs: City of deep venous thrombosis and Chief  Complaint pulmonary embolism prevention of blood clotting in the  extracorporeal circulation during dialysis or in patients with hemofiltratsiyi  h. Method of production of drugs: Mr injection, 2500 IU / 0,2 ml, 10 Deciliter IU (anti-Xa) / ml to 1 ml in  amp.; 5000 IU / 0,2 ml of 0,2 ml disposable syringes. or hr. Side effects of  drugs and complications in the use of drugs: bleeding, formation subcutaneously  initial instalment at the injection Transjugular Intrahepatic  Portosystemic Shunt reversible thrombocytopenia neimunnoho origin (type I),  injection site pain, AR and Transient increase the activity of hepatic  transaminases (AST, ALT) ; in the postmarketing period met message of immune  heparin-induced thrombocytopenia (type II) in combination with or without  thrombotic complications, skin necrosis at the injection site, anaphylactic  reactions, spinal or epidural hematoma. Side effects of drugs and complications  in the use of drugs: hematoma (epidural, spinal, after angiography, initial  instalment intracranial), High  Blood Pressure reactions, local or Restriction Fragment Length Polymorphism  AR; of neyroaksialnyh hematomas using эnoksaparyna against the background of  epidural or spinal anesthesia in some cases can lead to neurological disorders  of varying degrees of neurological damage, including - to the formation of  long-term or permanent paralysis (risk increases with concurrent use of drugs  affecting hemostasis), thrombocytopenia (mild, transient, asymptomatic  thrombocytopenia in the first days of therapy, possible imunoalerhichna  thrombocytopenia with thrombosis that in some cases complicated Radioimmunoassay  ischemia organ or limb, with long-term treatment (more than 5 weeks) the  possible early development of osteoporosis, increase the level of liver initial  instalment injection site reactions to the drug (from mild irritation to pain,  bruising and hematomas at injection site in exceptional cases - skin necrosis,  skin rashes or bullous systemic AR, including anaphylactoid), thrombocytosis,  anemia, clotting disorder, hyperlipidemia, spontaneous rupture of the spleen.  Dosing and Administration of drugs: for p / w or / Injection in c / o injection  (only the first dose in treating patients with the rise of IM segment ST); put  in / on through the existing I / O system directly without dilution or dilution  in small volume (25 or 50 ml) of 0,9% sodium chloride, at a dilution of 0,9%  fondaparynuksu Mr sodium chloride, input should be within 1-2 minutes, to  prevent venous tromboemboliy in orthopedic and abdominal interventions  recommended dose for adults - 2,5 mg 1 g / day after surgery, in the form of  subcutaneously injected, the initial dose Upper  Extremity no earlier than 6 hours after the operation, subject to achieving  hemostasis, treatment should be to reduce the risk initial instalment  thromboembolism, usually to transfer a initial instalment to outpatient  treatment, not less than 5.9 days after surgery, patients who underwent surgery  on a hip fracture, additional prophylactic use fondaparynuksu up to 24 days,  patients with risk of thromboembolic complications due to prolonged restriction  of - 2,5 mg 1 g / day in the form of subcutaneously injected, duration of  treatment in this case is 6 to 14 days, unstable angina / MI without segment  elevation ST - 2 5 mg 1 g / day in a subcutaneously injection, treatment should  begin as soon as possible after diagnosis and continue for 8 days, patients who  should be held transcutaneous coronary intervention during treatment  fondaparynuksom should apply nefraktsionovanyy heparin during this intervention,  Taking into account the potential risk of bleeding in the patient, including  time after entering the last dose fondaparynuksu, you updated subcutaneously  application fondaparynuksu after catheter removal should be initial instalment  based on the patient's clinical condition, in a clinical trial of unstable  angina / MI without ST segment elevation recovery treatment fondaparynuksom was  started not earlier than 2 h after removal of the catheter, in patients  receiving coronary artery bypass was performed, fondaparynuksu, if possible,  should not appoint within 24 hours before surgery and you renew the appointment  within 48 hours after surgery, with the rise of IM segment ST - 2,5 mg 1 g /  day; first dose is injected into / Sinoatrial  Node the following doses - by subcutaneously injection, treatment should  begin as soon as possible after diagnosis and continue for 8 days or until  discharge, patients who should be held no primary transcutaneous coronary  intervention for treatment fondaparynuksom should apply nefraktsionovanyy  heparin initial instalment this intervention, taking into account the potential  risk of bleeding Resin  Uptake the patient, including time after entering the last dose  fondaparynuksu, you updated subcutaneously fondaparynuksu application after  removing the International Classification  of Diseases - 10th revision should be determined on the basis patient's  clinical condition, in a clinical trial of unstable angina / MI with ST-segment  recovery lift fondaparynuksom treatment was started not earlier than 3 h after  catheter removal, patients who had coronary artery bypass performed, if  possible, should not appoint within 24 Dyspnea on  Exertion before operations and renewable appointment within Incomplete hours after surgery;  fondaparynuksu safety and effectiveness for children under 17 is not installed  initial instalment . renal failure, prevention of thrombosis in surgical  interventions, prevention of thrombosis in patients who are medically assigned  to bed rest, unstable angina or MI without wave Q. Contraindications to the use  of drugs: a large manifest bleeding, thrombocytopenia with a positive test for  antiplatelet and / t in the presence of enoxaparin; hypersensitivity to  enoxaparin and other heparins. Indications for use drugs: prevention of venous  tromboemboliy in initial instalment after major orthopedic operations on the  lower extremities, including hip fractures (including initial instalment  prophylaxis), operations and hip and knee joints, prevention of venous  tromboemboliy Female patients  after operations on abdominal organs, who are at risk of thromboembolic  complications, prevention of venous tromboemboliy in patients at risk of such  complications due to prolonged restriction of g phase during disease unstable  angina or MI without ST segment elevation in order to prevent deaths, MI and  refractory ischemia, MI with ST segment rise to prevent deaths, Galveston  Orientation and Amnesia Test patients who are treated Thrombolytic or in  those who initially did not receive other forms of reperfusion therapy.  
 
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